Assay Detail
Binding
CHEMBL968292
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of bovine tubulin polymerization
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Antineoplastic agents 440. Asymmetric synthesis and evaluation of the combretastatin A-1 SAR probes (1S,2S)- and (1R,2R)-1, 2-dihydroxy- 1-(2',3'-dihydroxy-4'-methoxyphenyl)-2-(3' ',4' ',5' '-trimethoxyphenyl)-ethane.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.30 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 6.00 |
| CHEMBL36255 | COMBRETASTATIN A-1 | 1.0 | 1 | 5.96 |
| CHEMBL447098 | — | — | 1 | 5.00 |
| CHEMBL36556 | — | — | 1 | 4.85 |
| CHEMBL485778 | — | — | 1 | 4.70 |
| CHEMBL289686 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL36255 | COMBRETASTATIN A-1 | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL447098 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL36556 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL485778 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL289686 | — | IC50 | > | 40000.0 | nM | - |