Assay Detail
Binding
CHEMBL968448
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Wistar rat kidney aldose reductase 1
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Carboxymethylated pyridoindole antioxidants as aldose reductase inhibitors: Synthesis, activity, partitioning, and molecular modeling.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.25 | 4.25 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL109 | VALPROIC ACID | 4.0 | 1 | 4.25 |
| CHEMBL477933 | — | — | 1 | - |
| CHEMBL479175 | — | — | 1 | - |
| CHEMBL476908 | — | — | 1 | - |
| CHEMBL477942 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL109 | VALPROIC ACID | IC50 | = | 56100.0 | nM | 4.25 |
| CHEMBL477933 | — | IC50 | = | 3081300.0 | nM | - |
| CHEMBL479175 | — | IC50 | > | 3000000.0 | nM | - |
| CHEMBL476908 | — | IC50 | = | 603000.0 | nM | - |
| CHEMBL477942 | — | IC50 | = | 328500.0 | nM | - |