Assay Detail
Functional
CHEMBL968472
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Antiproliferative activity against human HT29 cells microculture tetrazolium assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-29 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis, in vitro antiproliferative activities, and Chk1 inhibitory properties of pyrrolo[3,4-a]carbazole-1,3-diones, pyrrolo[3,4-c]carbazole-1,3-diones, and 2-aminopyridazino[3,4-a]pyrrolo[3,4-c]carbazole-1,3,4,7-tetraone.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 4.90 | 5.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL465738 | — | — | 1 | 5.41 |
| CHEMBL463663 | — | — | 1 | 5.40 |
| CHEMBL240747 | GRANULATIMIDE | — | 1 | 5.24 |
| CHEMBL517493 | — | — | 1 | 5.21 |
| CHEMBL517310 | — | — | 1 | 5.19 |
| CHEMBL406938 | — | — | 1 | 5.09 |
| CHEMBL388648 | BIS-IMIDE A | — | 1 | 5.01 |
| CHEMBL413188 | ISOGRANULATIMIDE | — | 1 | 4.86 |
| CHEMBL463661 | — | — | 1 | 4.50 |
| CHEMBL465739 | — | — | 1 | 4.48 |
| CHEMBL464685 | — | — | 1 | 4.33 |
| CHEMBL463662 | — | — | 1 | 4.07 |
| CHEMBL464684 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL465738 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL463663 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL240747 | GRANULATIMIDE | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL517493 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL517310 | — | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL406938 | — | IC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL388648 | BIS-IMIDE A | IC50 | = | 9700.0 | nM | 5.01 |
| CHEMBL413188 | ISOGRANULATIMIDE | IC50 | = | 13700.0 | nM | 4.86 |
| CHEMBL463661 | — | IC50 | = | 31700.0 | nM | 4.50 |
| CHEMBL465739 | — | IC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL464685 | — | IC50 | = | 46700.0 | nM | 4.33 |
| CHEMBL463662 | — | IC50 | = | 84900.0 | nM | 4.07 |
| CHEMBL464684 | — | IC50 | > | 100000.0 | nM | - |