Assay Detail
Binding
CHEMBL968707
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of kallikrein
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of betrixaban (PRT054021), N-(5-chloropyridin-2-yl)-2-(4-(N,N-dimethylcarbamimidoyl)benzamido)-5-methoxybenzamide, a highly potent, selective, and orally efficacious factor Xa inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.73 | 6.29 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL221906 | — | — | 1 | 6.29 |
| CHEMBL472967 | — | — | 1 | 6.27 |
| CHEMBL512351 | BETRIXABAN | 4.0 | 1 | 5.20 |
| CHEMBL515919 | — | — | 1 | 5.14 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL221906 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL472967 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL512351 | BETRIXABAN | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL515919 | — | IC50 | = | 7200.0 | nM | 5.14 |