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Assay Detail

CHEMBL968773

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Binding
Inhibition of Plasmodium falciparum protein farnesyltransferase by SPA method
ChEMBL ↗
36
Total Activities
36
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Plasmodium falciparum
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545) ↗
Type UNCHECKED

Publication

Efficacy, pharmacokinetics, and metabolism of tetrahydroquinoline inhibitors of Plasmodium falciparum protein farnesyltransferase.
Van Voorhis WC, Rivas KL, Bendale P, Nallan L, Hornéy C, Barrett LK, Bauer KD, Smart BP, Ankala S, Hucke O, Verlinde CL, Chakrabarti D, Strickland C, Yokoyama K, Buckner FS, Hamilton AD, Williams DK, Lombardo LJ, Floyd D, Gelb MH.
Antimicrob Agents Chemother (2007) 51 : 3659 -3671
PubMed 17606674 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 36 9.16 9.30

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL233718 — — 1 9.30
CHEMBL234796 — — 1 9.30
CHEMBL233922 — — 1 9.30
CHEMBL392236 — — 1 9.30
CHEMBL233921 — — 1 9.30
CHEMBL233717 — — 1 9.30
CHEMBL233719 — — 1 9.30
CHEMBL232104 — — 1 9.24
CHEMBL392235 — — 1 9.22
CHEMBL429443 — — 1 9.22
CHEMBL394085 — — 1 9.22
CHEMBL394086 — — 1 9.22
CHEMBL234151 — — 1 9.22
CHEMBL437565 — — 1 9.22
CHEMBL394407 — — 1 9.22
CHEMBL234359 — — 1 9.22
CHEMBL394696 — — 1 9.22
CHEMBL265603 — — 1 9.22
CHEMBL411803 — — 1 9.22
CHEMBL232122 — — 1 9.22
CHEMBL233941 — — 1 9.22
CHEMBL232523 — — 1 9.22
CHEMBL393371 — — 1 9.22
CHEMBL399827 — — 1 9.22
CHEMBL392237 — — 1 9.15
CHEMBL231898 — — 1 9.10
CHEMBL232484 — — 1 9.10
CHEMBL395217 — — 1 9.10
CHEMBL234975 — — 1 9.10
CHEMBL398057 — — 1 9.10

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL233718 — IC50 = 0.5 nM 9.30
CHEMBL234796 — IC50 = 0.5 nM 9.30
CHEMBL233922 — IC50 = 0.5 nM 9.30
CHEMBL392236 — IC50 = 0.5 nM 9.30
CHEMBL233921 — IC50 = 0.5 nM 9.30
CHEMBL233717 — IC50 = 0.5 nM 9.30
CHEMBL233719 — IC50 = 0.5 nM 9.30
CHEMBL232104 — IC50 = 0.58 nM 9.24
CHEMBL394407 — IC50 = 0.6 nM 9.22
CHEMBL429443 — IC50 = 0.6 nM 9.22
CHEMBL394085 — IC50 = 0.6 nM 9.22
CHEMBL394086 — IC50 = 0.6 nM 9.22
CHEMBL234151 — IC50 = 0.6 nM 9.22
CHEMBL437565 — IC50 = 0.6 nM 9.22
CHEMBL234359 — IC50 = 0.6 nM 9.22
CHEMBL394696 — IC50 = 0.6 nM 9.22
CHEMBL265603 — IC50 = 0.6 nM 9.22
CHEMBL411803 — IC50 = 0.6 nM 9.22
CHEMBL232122 — IC50 = 0.6 nM 9.22
CHEMBL233941 — IC50 = 0.6 nM 9.22
CHEMBL232523 — IC50 = 0.6 nM 9.22
CHEMBL393371 — IC50 = 0.6 nM 9.22
CHEMBL399827 — IC50 = 0.6 nM 9.22
CHEMBL392235 — IC50 = 0.6 nM 9.22
CHEMBL392237 — IC50 = 0.7 nM 9.15
CHEMBL232484 — IC50 = 0.8 nM 9.10
CHEMBL393970 — IC50 = 0.8 nM 9.10
CHEMBL231805 — IC50 = 0.8 nM 9.10
CHEMBL398057 — IC50 = 0.8 nM 9.10
CHEMBL234975 — IC50 = 0.8 nM 9.10
CHEMBL395217 — IC50 = 0.8 nM 9.10
CHEMBL231898 — IC50 = 0.8 nM 9.10
CHEMBL373337 — IC50 = 1.0 nM 9.00
CHEMBL231662 — IC50 = 1.5 nM 8.82
CHEMBL195168 — IC50 = 10.0 nM 8.00
CHEMBL372017 — IC50 > 50.0 nM -