Assay Detail
Binding
CHEMBL968896
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human NTPDase 2 expressed in HEK293 cells assessed as residual activity by capillary electrophoresis
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Ectonucleoside triphosphate diphosphohydrolase 2 (CHEMBL5049) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Selective nucleoside triphosphate diphosphohydrolase-2 (NTPDase2) inhibitors: nucleotide mimetics derived from uridine-5'-carboxamide.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 4.38 | 4.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL469212 | — | — | 1 | 4.38 |
| CHEMBL469243 | — | — | 1 | - |
| CHEMBL468354 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL469212 | — | IC50 | = | 42000.0 | nM | 4.38 |
| CHEMBL469243 | — | IC50 | = | 101000.0 | nM | - |
| CHEMBL468354 | — | IC50 | = | 374000.0 | nM | - |