Assay Detail
Functional
CHEMBL968941
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Antimalarial activity after 48 hrs against chloroquine-sensitive Plasmodium falciparum 3D7 by [3H]hypoxanthine uptake
64
Total Activities
64
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and structure-activity relationship of 3-phenylquinoxaline 1,4-di-N-oxide derivatives as antimalarial agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 64 | 5.84 | 7.87 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 7.87 |
| CHEMBL490288 | — | — | 1 | 6.48 |
| CHEMBL472909 | — | — | 1 | 6.32 |
| CHEMBL490289 | — | — | 1 | 6.18 |
| CHEMBL490074 | — | — | 1 | 6.15 |
| CHEMBL489880 | — | — | 1 | 6.14 |
| CHEMBL514296 | — | — | 1 | 6.14 |
| CHEMBL490075 | — | — | 1 | 6.12 |
| CHEMBL473109 | — | — | 1 | 6.09 |
| CHEMBL514456 | — | — | 1 | 6.06 |
| CHEMBL472720 | — | — | 1 | 6.06 |
| CHEMBL490076 | — | — | 1 | 6.03 |
| CHEMBL512752 | — | — | 1 | 6.00 |
| CHEMBL454945 | — | — | 1 | 5.93 |
| CHEMBL473520 | — | — | 1 | 5.90 |
| CHEMBL451452 | — | — | 1 | 5.90 |
| CHEMBL516030 | — | — | 1 | 5.89 |
| CHEMBL460705 | — | — | 1 | 5.83 |
| CHEMBL460704 | — | — | 1 | 5.81 |
| CHEMBL523962 | — | — | 1 | 5.81 |
| CHEMBL521926 | — | — | 1 | 5.77 |
| CHEMBL454151 | — | — | 1 | 5.71 |
| CHEMBL454152 | — | — | 1 | 5.69 |
| CHEMBL475143 | — | — | 1 | 5.67 |
| CHEMBL475131 | — | — | 1 | 5.64 |
| CHEMBL460703 | — | — | 1 | 5.63 |
| CHEMBL510626 | — | — | 1 | 5.61 |
| CHEMBL445501 | — | — | 1 | 5.56 |
| CHEMBL445089 | — | — | 1 | 5.52 |
| CHEMBL473324 | — | — | 1 | 5.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL76 | CHLOROQUINE | IC50 | = | 13.5 | nM | 7.87 |
| CHEMBL490288 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL472909 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL490289 | — | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL490074 | — | IC50 | = | 710.0 | nM | 6.15 |
| CHEMBL489880 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL514296 | — | IC50 | = | 730.0 | nM | 6.14 |
| CHEMBL490075 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL473109 | — | IC50 | = | 810.0 | nM | 6.09 |
| CHEMBL514456 | — | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL472720 | — | IC50 | = | 880.0 | nM | 6.06 |
| CHEMBL490076 | — | IC50 | = | 930.0 | nM | 6.03 |
| CHEMBL512752 | — | IC50 | = | 1010.0 | nM | 6.00 |
| CHEMBL454945 | — | IC50 | = | 1180.0 | nM | 5.93 |
| CHEMBL451452 | — | IC50 | = | 1260.0 | nM | 5.90 |
| CHEMBL473520 | — | IC50 | = | 1270.0 | nM | 5.90 |
| CHEMBL516030 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL460705 | — | IC50 | = | 1470.0 | nM | 5.83 |
| CHEMBL460704 | — | IC50 | = | 1550.0 | nM | 5.81 |
| CHEMBL523962 | — | IC50 | = | 1560.0 | nM | 5.81 |
| CHEMBL521926 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL454151 | — | IC50 | = | 1930.0 | nM | 5.71 |
| CHEMBL454152 | — | IC50 | = | 2030.0 | nM | 5.69 |
| CHEMBL475143 | — | IC50 | = | 2150.0 | nM | 5.67 |
| CHEMBL475131 | — | IC50 | = | 2290.0 | nM | 5.64 |
| CHEMBL460703 | — | IC50 | = | 2350.0 | nM | 5.63 |
| CHEMBL510626 | — | IC50 | = | 2440.0 | nM | 5.61 |
| CHEMBL445501 | — | IC50 | = | 2770.0 | nM | 5.56 |
| CHEMBL445089 | — | IC50 | = | 3020.0 | nM | 5.52 |
| CHEMBL473324 | — | IC50 | = | 3140.0 | nM | 5.50 |
| CHEMBL475144 | — | IC50 | = | 3160.0 | nM | 5.50 |
| CHEMBL453122 | — | IC50 | = | 3220.0 | nM | 5.49 |
| CHEMBL472910 | — | IC50 | = | 3460.0 | nM | 5.46 |
| CHEMBL475290 | — | IC50 | = | 3910.0 | nM | 5.41 |
| CHEMBL489291 | — | IC50 | = | 4210.0 | nM | 5.38 |
| CHEMBL489290 | — | IC50 | = | 5780.0 | nM | 5.24 |
| CHEMBL472719 | — | IC50 | = | 5830.0 | nM | 5.23 |
| CHEMBL449174 | — | IC50 | = | 6540.0 | nM | 5.18 |
| CHEMBL454153 | — | IC50 | - | — | - | |
| CHEMBL517414 | — | IC50 | > | 7000.0 | nM | - |
| CHEMBL454944 | — | IC50 | > | 7000.0 | nM | - |
| CHEMBL490275 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL506804 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL512751 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL522442 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL489882 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL475132 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL475142 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL453121 | — | IC50 | - | — | - | |
| CHEMBL460713 | — | IC50 | > | 10000.0 | nM | - |