Assay Detail
Functional
CHEMBL968942
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Antimalarial activity after 48 hrs against chloroquine-resistant Plasmodium falciparum K1 by [3H]hypoxanthine uptake
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and structure-activity relationship of 3-phenylquinoxaline 1,4-di-N-oxide derivatives as antimalarial agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 6.22 | 6.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL490288 | — | — | 1 | 6.75 |
| CHEMBL472909 | — | — | 1 | 6.72 |
| CHEMBL473520 | — | — | 1 | 6.57 |
| CHEMBL514456 | — | — | 1 | 6.44 |
| CHEMBL472720 | — | — | 1 | 6.43 |
| CHEMBL490075 | — | — | 1 | 6.42 |
| CHEMBL512752 | — | — | 1 | 6.39 |
| CHEMBL514296 | — | — | 1 | 6.33 |
| CHEMBL490289 | — | — | 1 | 6.28 |
| CHEMBL454151 | — | — | 1 | 6.26 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 6.17 |
| CHEMBL460705 | — | — | 1 | 6.14 |
| CHEMBL460704 | — | — | 1 | 6.13 |
| CHEMBL489880 | — | — | 1 | 6.06 |
| CHEMBL490074 | — | — | 1 | 6.03 |
| CHEMBL451452 | — | — | 1 | 6.03 |
| CHEMBL516030 | — | — | 1 | 6.02 |
| CHEMBL490076 | — | — | 1 | 5.90 |
| CHEMBL523962 | — | — | 1 | 5.75 |
| CHEMBL473109 | — | — | 1 | 5.64 |
| CHEMBL521926 | — | — | 1 | - |
| CHEMBL454945 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL490288 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL472909 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL473520 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL514456 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL472720 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL490075 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL512752 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL514296 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL490289 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL454151 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 682.0 | nM | 6.17 |
| CHEMBL460705 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL460704 | — | IC50 | = | 740.0 | nM | 6.13 |
| CHEMBL489880 | — | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL490074 | — | IC50 | = | 930.0 | nM | 6.03 |
| CHEMBL451452 | — | IC50 | = | 930.0 | nM | 6.03 |
| CHEMBL516030 | — | IC50 | = | 950.0 | nM | 6.02 |
| CHEMBL490076 | — | IC50 | = | 1250.0 | nM | 5.90 |
| CHEMBL523962 | — | IC50 | = | 1770.0 | nM | 5.75 |
| CHEMBL473109 | — | IC50 | = | 2290.0 | nM | 5.64 |
| CHEMBL521926 | — | IC50 | > | 8000.0 | nM | - |
| CHEMBL454945 | — | IC50 | > | 10000.0 | nM | - |