Assay Detail
Functional
CHEMBL969118
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Antiproliferative activity against human MCF7 cells by MTT assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Search for Hsp90 inhibitors with potential anticancer activity: isolation and SAR studies of radicicol and monocillin I from two plant-associated fungi of the Sonoran desert.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.69 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL414883 | RADICICOL | — | 1 | 7.52 |
| CHEMBL495482 | TETRAHYDRORADICICOL | — | 1 | 6.72 |
| CHEMBL215853 | MONOCILLIN I | — | 1 | 6.47 |
| CHEMBL491886 | MONOMETHYL RADICICOL | — | 1 | 6.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL414883 | RADICICOL | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL495482 | TETRAHYDRORADICICOL | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL215853 | MONOCILLIN I | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL491886 | MONOMETHYL RADICICOL | IC50 | = | 900.0 | nM | 6.05 |