Assay Detail
Functional
CHEMBL969246
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Antiproliferative activity against human SW620 cells after 72 hrs by MTT test
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SW-620 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel thiosemicarbazone derivatives as potential antitumor agents: Synthesis, physicochemical and structural properties, DNA interactions and antiproliferative activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.91 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL522881 | — | — | 1 | 6.52 |
| CHEMBL242114 | — | — | 1 | 6.30 |
| CHEMBL493188 | — | — | 1 | 6.22 |
| CHEMBL493189 | — | — | 1 | 5.80 |
| CHEMBL463836 | — | — | 1 | 5.70 |
| CHEMBL493606 | — | — | 1 | 5.52 |
| CHEMBL505209 | — | — | 1 | 5.33 |
| CHEMBL242112 | SALICYLALDEHYDE THIOSEMICARBAZONE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL522881 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL242114 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL493188 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL493189 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL463836 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL493606 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL505209 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL242112 | SALICYLALDEHYDE THIOSEMICARBAZONE | IC50 | > | 5000.0 | nM | - |