Assay Detail
Functional
CHEMBL969286
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Cytotoxicity against human PC3 cells by resazurin reduction test
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | PC-3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and cytotoxic properties of new fluorodeoxyglucose-coupled chlorambucil derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.33 | 5.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL500328 | — | — | 1 | 5.85 |
| CHEMBL450957 | — | — | 1 | 5.52 |
| CHEMBL446753 | — | — | 1 | 5.43 |
| CHEMBL475291 | — | — | 1 | 5.40 |
| CHEMBL515128 | — | — | 1 | 5.36 |
| CHEMBL447306 | — | — | 1 | 5.10 |
| CHEMBL501118 | — | — | 1 | 5.00 |
| CHEMBL500999 | — | — | 1 | 4.96 |
| CHEMBL515 | CHLORAMBUCIL | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL500328 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL450957 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL446753 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL475291 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL515128 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL447306 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL501118 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL500999 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL515 | CHLORAMBUCIL | IC50 | - | — | - |