Assay Detail

CHEMBL969402

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional

Inhibition of LPS-stimulated TNFalpha production in p38beta deficient mouse peritoneal exudates cells by ELISA

ChEMBL ↗

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Target

Unchecked (CHEMBL612545) ↗

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Primary target Unchecked

CHEMBL612545

Anchored from Assay target.

Protein identity Unchecked

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Mus musculus
Confidence	0 — Uncurated / Unknown
Curated By	Autocuration

Target

Unchecked (CHEMBL612545) ↗

Type

UNCHECKED

Publication

Chemical genetics define the roles of p38alpha and p38beta in acute and chronic inflammation.

O'Keefe SJ, Mudgett JS, Cupo S, Parsons JN, Chartrain NA, Fitzgerald C, Chen SL, Lowitz K, Rasa C, Visco D, Luell S, Carballo-Jane E, Owens K, Zaller DM.
J Biol Chem (2007) 282 : 34663 -34671
PubMed 17855341 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	8.17	8.17

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL199679	—	—	1	8.17

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL199679	—	IC50	=	6.8	nM	8.17