Assay Detail
Binding
CHEMBL969513
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [125I]T3 from recombinant thyroid hormone receptor beta expressed in sf9 cells by scintillation proximity assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | Sf9 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Targeting thyroid hormone receptor-beta agonists to the liver reduces cholesterol and triglycerides and improves the therapeutic index.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 8.05 | 9.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL41036 | — | — | 1 | 9.43 |
| CHEMBL1544 | LIOTHYRONINE | 4.0 | 1 | 9.26 |
| CHEMBL471488 | MB07344 | -1.0 | 1 | 8.66 |
| CHEMBL471897 | MB07811 | 2.0 | 1 | 4.84 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL41036 | — | Ki | = | 0.37 | nM | 9.43 |
| CHEMBL1544 | LIOTHYRONINE | Ki | = | 0.55 | nM | 9.26 |
| CHEMBL471488 | MB07344 | Ki | = | 2.17 | nM | 8.66 |
| CHEMBL471897 | MB07811 | Ki | = | 14600.0 | nM | 4.84 |