Assay Detail
Functional
CHEMBL969628
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against Human cytomegalovirus AD169 infected in human foreskin fibroblast cells assessed as inhibition of virus-induced cytopathic effect
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human betaherpesvirus 5 |
| Cell Type | Fibroblast |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
(Z)- and (E)-2-(1,2-dihydroxyethyl)methylenecyclopropane analogues of 2'-deoxyadenosine and 2'-deoxyguanosine. Synthesis of all stereoisomers, absolute configuration, and antiviral activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 18 | 6.28 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL182 | GANCICLOVIR | 4.0 | 1 | 7.40 |
| CHEMBL265948 | FILOCICLOVIR | 2.0 | 1 | 6.31 |
| CHEMBL491554 | — | — | 1 | 5.12 |
| CHEMBL492126 | — | — | 1 | - |
| CHEMBL445511 | — | — | 1 | - |
| CHEMBL450896 | — | — | 1 | - |
| CHEMBL509125 | — | — | 1 | - |
| CHEMBL489519 | — | — | 1 | - |
| CHEMBL492102 | — | — | 1 | - |
| CHEMBL523282 | — | — | 1 | - |
| CHEMBL521594 | — | — | 1 | - |
| CHEMBL489944 | — | — | 1 | - |
| CHEMBL491911 | — | — | 1 | - |
| CHEMBL522130 | — | — | 1 | - |
| CHEMBL489950 | — | — | 1 | - |
| CHEMBL489949 | — | — | 1 | - |
| CHEMBL489948 | — | — | 1 | - |
| CHEMBL506599 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL182 | GANCICLOVIR | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL265948 | FILOCICLOVIR | EC50 | = | 490.0 | nM | 6.31 |
| CHEMBL491554 | — | EC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL492126 | — | EC50 | = | 300000.0 | nM | - |
| CHEMBL445511 | — | EC50 | > | 60000.0 | nM | - |
| CHEMBL450896 | — | EC50 | > | 60000.0 | nM | - |
| CHEMBL509125 | — | EC50 | > | 60000.0 | nM | - |
| CHEMBL489519 | — | EC50 | > | 60000.0 | nM | - |
| CHEMBL492102 | — | EC50 | > | 60000.0 | nM | - |
| CHEMBL523282 | — | EC50 | > | 60000.0 | nM | - |
| CHEMBL521594 | — | EC50 | > | 60000.0 | nM | - |
| CHEMBL489944 | — | EC50 | > | 60000.0 | nM | - |
| CHEMBL491911 | — | EC50 | > | 300000.0 | nM | - |
| CHEMBL522130 | — | EC50 | > | 300000.0 | nM | - |
| CHEMBL489950 | — | EC50 | > | 300000.0 | nM | - |
| CHEMBL489949 | — | EC50 | > | 300000.0 | nM | - |
| CHEMBL489948 | — | EC50 | > | 300000.0 | nM | - |
| CHEMBL506599 | — | EC50 | > | 300000.0 | nM | - |