Assay Detail
Functional
CHEMBL969662
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Antiproliferative activity against human HT-29 cells after 4 days by celltiter assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-29 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
A class of 2,4-bisanilinopyrimidine Aurora A inhibitors with unusually high selectivity against Aurora B.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.34 | 6.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL259084 | MLN-8054 | 1.0 | 1 | 6.82 |
| CHEMBL502124 | — | — | 1 | 5.54 |
| CHEMBL508307 | — | — | 1 | 5.21 |
| CHEMBL523991 | — | — | 1 | 5.14 |
| CHEMBL521949 | — | — | 1 | 4.77 |
| CHEMBL507170 | — | — | 1 | 4.57 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL259084 | MLN-8054 | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL502124 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL508307 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL523991 | — | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL521949 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL507170 | — | IC50 | = | 27000.0 | nM | 4.57 |