Assay Detail
Functional
CHEMBL969875
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Antiviral activity against HCMV Davis infected in HEL cells assessed as reduction of virus-induced cytopathogenicity after 3 days
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human betaherpesvirus 5 |
| Cell Type | HEL |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
The novel primaquine derivatives of N-alkyl, cycloalkyl or aryl urea: synthesis, cytostatic and antiviral activity evaluations.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 12 | 5.38 | 6.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5314375 | CIDOFOVIR | 4.0 | 1 | 6.39 |
| CHEMBL508468 | — | — | 1 | 5.92 |
| CHEMBL182 | GANCICLOVIR | 4.0 | 1 | 5.89 |
| CHEMBL488856 | — | — | 1 | 5.54 |
| CHEMBL455391 | — | — | 1 | 5.12 |
| CHEMBL528548 | — | — | 1 | 5.12 |
| CHEMBL455151 | — | — | 1 | 4.98 |
| CHEMBL455416 | — | — | 1 | 4.92 |
| CHEMBL455417 | — | — | 1 | 4.58 |
| CHEMBL455150 | PRIMAQUINE BENZOTRIAZOLIDE | — | 1 | - |
| CHEMBL455392 | — | — | 1 | - |
| CHEMBL453609 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5314375 | CIDOFOVIR | EC50 | = | 410.0 | nM | 6.39 |
| CHEMBL508468 | — | EC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL182 | GANCICLOVIR | EC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL488856 | — | EC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL455391 | — | EC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL528548 | — | EC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL455151 | — | EC50 | = | 10500.0 | nM | 4.98 |
| CHEMBL455416 | — | EC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL455417 | — | EC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL455150 | PRIMAQUINE BENZOTRIAZOLIDE | EC50 | > | 30000.0 | nM | - |
| CHEMBL455392 | — | EC50 | > | 800.0 | nM | - |
| CHEMBL453609 | — | EC50 | > | 100000.0 | nM | - |