Assay Detail
Binding
CHEMBL969894
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Inhibition of human COX2
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Investigations concerning the COX/5-LOX inhibiting and hydroxyl radical scavenging potencies of novel 4,5-diaryl isoselenazoles.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.77 | 6.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL452744 | — | — | 1 | 6.22 |
| CHEMBL118 | CELECOXIB | 4.0 | 1 | 6.00 |
| CHEMBL470304 | — | — | 1 | 5.10 |
| CHEMBL134342 | THIOCTIC ACID | — | 1 | - |
| CHEMBL51085 | EBSELEN | 3.0 | 1 | - |
| CHEMBL501676 | — | — | 1 | - |
| CHEMBL471171 | — | — | 1 | - |
| CHEMBL513405 | — | — | 1 | - |
| CHEMBL452730 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL452744 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL118 | CELECOXIB | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL470304 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL134342 | THIOCTIC ACID | IC50 | = | - | nM | - |
| CHEMBL51085 | EBSELEN | IC50 | = | - | nM | - |
| CHEMBL501676 | — | IC50 | = | - | nM | - |
| CHEMBL471171 | — | IC50 | = | - | nM | - |
| CHEMBL513405 | — | IC50 | = | - | nM | - |
| CHEMBL452730 | — | IC50 | = | - | nM | - |