Assay Detail
Functional
CHEMBL970001
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antimalarial activity after 48 hrs against chloroquine-sensitive Plasmodium falciparum T9-96 by LDH reporter assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Activity of extracts and isolated naphthoquinones from Kigelia pinnata against Plasmodium falciparum.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.71 | 6.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL58510 | CHLOROQUINE PHOSPHATE | 4.0 | 1 | 6.64 |
| CHEMBL294323 | — | — | 1 | 6.20 |
| CHEMBL485982 | ISOPINNATAL | — | 1 | 6.12 |
| CHEMBL485984 | ISOKIGELINOL | — | 1 | 4.82 |
| CHEMBL485983 | KIGELINOL | — | 1 | 4.78 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL58510 | CHLOROQUINE PHOSPHATE | IC50 | = | 228.0 | nM | 6.64 |
| CHEMBL294323 | — | IC50 | = | 627.0 | nM | 6.20 |
| CHEMBL485982 | ISOPINNATAL | IC50 | = | 763.0 | nM | 6.12 |
| CHEMBL485984 | ISOKIGELINOL | IC50 | = | 15200.0 | nM | 4.82 |
| CHEMBL485983 | KIGELINOL | IC50 | = | 16660.0 | nM | 4.78 |