Assay Detail
Functional
CHEMBL970002
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Antimalarial activity after 48 hrs against chloroquine-resistant Plasmodium falciparum K1 by LDH reporter assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Activity of extracts and isolated naphthoquinones from Kigelia pinnata against Plasmodium falciparum.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.80 | 7.29 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL58510 | CHLOROQUINE PHOSPHATE | 4.0 | 1 | 7.29 |
| CHEMBL294323 | — | — | 1 | 6.14 |
| CHEMBL485982 | ISOPINNATAL | — | 1 | 5.81 |
| CHEMBL485984 | ISOKIGELINOL | — | 1 | 4.92 |
| CHEMBL485983 | KIGELINOL | — | 1 | 4.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL58510 | CHLOROQUINE PHOSPHATE | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL294323 | — | IC50 | = | 718.0 | nM | 6.14 |
| CHEMBL485982 | ISOPINNATAL | IC50 | = | 1552.0 | nM | 5.81 |
| CHEMBL485984 | ISOKIGELINOL | IC50 | = | 11930.0 | nM | 4.92 |
| CHEMBL485983 | KIGELINOL | IC50 | = | 15200.0 | nM | 4.82 |