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Assay Detail

CHEMBL970276

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of p38beta T106M mutant
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Mitogen-activated protein kinase 11 (CHEMBL3961)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Chemical genetics define the roles of p38alpha and p38beta in acute and chronic inflammation.
O'Keefe SJ, Mudgett JS, Cupo S, Parsons JN, Chartrain NA, Fitzgerald C, Chen SL, Lowitz K, Rasa C, Visco D, Luell S, Carballo-Jane E, Owens K, Zaller DM.
J Biol Chem (2007) 282 : 34663 -34671
PubMed 17855341 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 1 6.58 6.58

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL199679 1 6.58

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL199679 IC50 = 260.0 nM 6.58