Assay Detail

CHEMBL970479

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional

Antiviral activity against Influenza A virus (A/R(duck/Mongolia/54/01-duck/Mongolia/47/01) (H5N1)) assessed viral plaque reduction

ChEMBL ↗

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Target

H5N1 subtype (CHEMBL613845) ↗

Open DB target context

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H5N1 subtype (CHEMBL613845) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target H5N1 subtype

CHEMBL613845

Anchored from Assay target.

Protein identity H5N1 subtype

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Influenza A virus (A/R(duck/Mongolia/54/01-duck/Mongolia/47/01)(H5N1))
Confidence	1 — Organism
Curated By	Autocuration

Target

H5N1 subtype (CHEMBL613845) ↗

Type	ORGANISM
Organism	H5N1 subtype

Publication

Synthesis and in vivo influenza virus-inhibitory effect of ester prodrug of 4-guanidino-7-O-methyl-Neu5Ac2en.

Honda T, Kubo S, Masuda T, Arai M, Kobayashi Y, Yamashita M.
Bioorg Med Chem Lett (2009) 19 : 2938 -2940
PubMed 19414262 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	2	9.29	9.47

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL466246	LANINAMIVIR	2.0	1	9.47
CHEMBL222813	ZANAMIVIR	4.0	1	9.10

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL466246	LANINAMIVIR	IC50	=	0.34	nM	9.47
CHEMBL222813	ZANAMIVIR	IC50	=	0.79	nM	9.10