Assay Detail
Binding
CHEMBL970498
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Inhibition of human COX2 by enzyme immunoassay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Dinitroglyceryl and diazen-1-ium-1,2-diolated nitric oxide donor ester prodrugs of aspirin, indomethacin and ibuprofen: synthesis, biological evaluation and nitric oxide release studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.50 | 6.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL466447 | — | — | 1 | 6.22 |
| CHEMBL466243 | — | — | 1 | 5.77 |
| CHEMBL466861 | — | — | 1 | 5.66 |
| CHEMBL466863 | — | — | 1 | 5.19 |
| CHEMBL467905 | — | — | 1 | 5.11 |
| CHEMBL466862 | — | — | 1 | 5.03 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL466447 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL466243 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL466861 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL466863 | — | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL467905 | — | IC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL466862 | — | IC50 | = | 9300.0 | nM | 5.03 |