Assay Detail
Binding
CHEMBL970546
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [35S](2S,3S,4S,5R,6S)-6-(4-((2S,3R)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)-1-(4-(3-(methylsulfonamido)prop-1-ynyl)phenyl)-4-oxoazetidin-2-yl)phenoxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic acid from NPC1L1 in pig enterocyte brush border membrane
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sus scrofa |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Spiroimidazolidinone NPC1L1 inhibitors. 1: Discovery by 3D-similarity-based virtual screening.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.20 | 7.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL504066 | — | — | 1 | 7.89 |
| CHEMBL321017 | — | — | 1 | 6.50 |
| CHEMBL466849 | — | — | 1 | - |
| CHEMBL468523 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL504066 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL321017 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL466849 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL468523 | — | IC50 | > | 500000.0 | nM | - |