Assay Detail
Binding
CHEMBL970607
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Inhibition of human recombinant SIRT1
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
NAD-dependent protein deacetylase sirtuin-1 (CHEMBL4506) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Novel cambinol analogs as sirtuin inhibitors: synthesis, biological evaluation, and rationalization of activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 4.44 | 4.90 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL521799 | — | — | 1 | 4.90 |
| CHEMBL448638 | — | — | 1 | 4.42 |
| CHEMBL491960 | CAMBINOL | — | 1 | 4.39 |
| CHEMBL491927 | — | — | 1 | 4.37 |
| CHEMBL489527 | — | — | 1 | 4.36 |
| CHEMBL491896 | — | — | 1 | 4.35 |
| CHEMBL491573 | — | — | 1 | 4.30 |
| CHEMBL490736 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL521799 | — | IC50 | = | 12700.0 | nM | 4.90 |
| CHEMBL448638 | — | IC50 | = | 38300.0 | nM | 4.42 |
| CHEMBL491960 | CAMBINOL | IC50 | = | 40700.0 | nM | 4.39 |
| CHEMBL491927 | — | IC50 | = | 43000.0 | nM | 4.37 |
| CHEMBL489527 | — | IC50 | = | 44200.0 | nM | 4.36 |
| CHEMBL491896 | — | IC50 | = | 44500.0 | nM | 4.35 |
| CHEMBL491573 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL490736 | — | IC50 | > | 90000.0 | nM | - |