Assay Detail
Binding
CHEMBL970762
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Inhibition of TGH
40
Total Activities
40
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Optimization of the central heterocycle of alpha-ketoheterocycle inhibitors of fatty acid amide hydrolase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 40 | 6.27 | 9.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL448922 | — | — | 1 | 9.15 |
| CHEMBL469050 | — | — | 1 | 8.00 |
| CHEMBL220125 | — | — | 1 | 7.70 |
| CHEMBL467796 | — | — | 1 | 7.60 |
| CHEMBL469198 | — | — | 1 | 7.52 |
| CHEMBL467817 | — | — | 1 | 7.40 |
| CHEMBL456450 | — | — | 1 | 7.10 |
| CHEMBL426967 | — | — | 1 | 7.10 |
| CHEMBL477371 | — | — | 1 | 7.00 |
| CHEMBL467368 | — | — | 1 | 6.92 |
| CHEMBL178398 | — | — | 1 | 6.85 |
| CHEMBL512965 | — | — | 1 | 6.82 |
| CHEMBL468189 | — | — | 1 | 6.70 |
| CHEMBL178071 | — | — | 1 | 6.70 |
| CHEMBL178115 | — | — | 1 | 6.60 |
| CHEMBL177356 | — | — | 1 | 6.52 |
| CHEMBL220784 | — | — | 1 | 6.52 |
| CHEMBL469051 | — | — | 1 | 6.40 |
| CHEMBL177577 | — | — | 1 | 6.22 |
| CHEMBL173992 | — | — | 1 | 6.16 |
| CHEMBL476511 | — | — | 1 | 6.10 |
| CHEMBL477372 | — | — | 1 | 5.82 |
| CHEMBL468221 | — | — | 1 | 5.70 |
| CHEMBL468188 | — | — | 1 | 5.70 |
| CHEMBL512107 | — | — | 1 | 5.52 |
| CHEMBL455556 | — | — | 1 | 5.30 |
| CHEMBL219880 | — | — | 1 | 5.22 |
| CHEMBL468222 | — | — | 1 | 5.10 |
| CHEMBL450158 | — | — | 1 | 4.96 |
| CHEMBL467182 | — | — | 1 | 4.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL448922 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL469050 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL220125 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL467796 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL469198 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL467817 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL456450 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL426967 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL477371 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL467368 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL178398 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL512965 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL468189 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL178071 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL178115 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL177356 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL220784 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL469051 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL177577 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL173992 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL476511 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL477372 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL468221 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL468188 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL512107 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL455556 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL219880 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL468222 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL450158 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL467182 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL477167 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL461163 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL466961 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL478424 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL468220 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL219942 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL504330 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL476512 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL478187 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL515490 | — | IC50 | > | 100000.0 | nM | - |