Assay Detail
Binding
CHEMBL970795
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Inhibition of Electrophorus electricus AChE by Ellman's method
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Electrophorus electricus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
New tacrine-dihydropyridine hybrids that inhibit acetylcholinesterase, calcium entry, and exhibit neuroprotection properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 6.95 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL95 | TACRINE | 4.0 | 1 | 7.70 |
| CHEMBL513161 | — | — | 1 | 7.41 |
| CHEMBL468001 | — | — | 1 | 7.38 |
| CHEMBL512096 | — | — | 1 | 7.21 |
| CHEMBL468000 | — | — | 1 | 6.97 |
| CHEMBL468002 | — | — | 1 | 6.80 |
| CHEMBL345124 | PROPIDIUM | — | 1 | 5.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL95 | TACRINE | Ki | = | 20.2 | nM | 7.70 |
| CHEMBL513161 | — | Ki | = | 38.9 | nM | 7.41 |
| CHEMBL468001 | — | Ki | = | 41.9 | nM | 7.38 |
| CHEMBL512096 | — | Ki | = | 61.3 | nM | 7.21 |
| CHEMBL468000 | — | Ki | = | 106.0 | nM | 6.97 |
| CHEMBL468002 | — | Ki | = | 157.0 | nM | 6.80 |
| CHEMBL345124 | PROPIDIUM | Ki | = | 6800.0 | nM | 5.17 |