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Assay Detail

CHEMBL971341

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiproliferative activity against human U251 cells assessed as cell number after 48 hrs by crystal violet assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type U-251
Confidence 1 — Organism
Curated By Autocuration

Target

U-251 (CHEMBL615022)
Type CELL-LINE
Organism Homo sapiens

Publication

Antiglioma action of xanthones from Gentiana kochiana: Mechanistic and structure-activity requirements.
Isakovic A, Jankovic T, Harhaji L, Kostic-Rajacic S, Nikolic Z, Vajs V, Trajkovic V.
Bioorg Med Chem (2008) 16 : 5683 -5694
PubMed 18406151 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 8 4.42 4.56

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL187044 GENTIAKOCHIANIN 1 4.56
CHEMBL467590 GETIACAULEIN 1 4.27
CHEMBL468999 ISOGENTIAKOCHIANOSIDE 1 -
CHEMBL501591 GENTIABAVAROSIDE 1 -
CHEMBL511949 1 -
CHEMBL26323 DECUSSATIN 1 -
CHEMBL184574 DEMETHYLBELLIDIFOLIN 1 -
CHEMBL185776 BELLIDIFOLIN 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL187044 GENTIAKOCHIANIN IC50 = 27300.0 nM 4.56
CHEMBL467590 GETIACAULEIN IC50 = 53200.0 nM 4.27
CHEMBL468999 ISOGENTIAKOCHIANOSIDE IC50 > 100000.0 nM -
CHEMBL501591 GENTIABAVAROSIDE IC50 > 100000.0 nM -
CHEMBL511949 IC50 > 100000.0 nM -
CHEMBL26323 DECUSSATIN IC50 > 100000.0 nM -
CHEMBL184574 DEMETHYLBELLIDIFOLIN IC50 > 100000.0 nM -
CHEMBL185776 BELLIDIFOLIN IC50 > 100000.0 nM -