Assay Detail
Functional
CHEMBL971390
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Agonist activity at human dopamine D2L receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Bioisosteric heterocyclic versions of 7-{[2-(4-phenyl-piperazin-1-yl)ethyl]propylamino}-5,6,7,8-tetrahydronaphthalen-2-ol: identification of highly potent and selective agonists for dopamine D3 receptor with potent in vivo activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 7.41 | 7.87 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL468017 | — | — | 1 | 7.87 |
| CHEMBL467540 | — | — | 1 | 7.70 |
| CHEMBL285755 | — | — | 1 | 7.40 |
| CHEMBL59 | DOPAMINE | 4.0 | 1 | 6.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL468017 | — | EC50 | = | 13.4 | nM | 7.87 |
| CHEMBL467540 | — | EC50 | = | 19.9 | nM | 7.70 |
| CHEMBL285755 | — | EC50 | = | 39.8 | nM | 7.40 |
| CHEMBL59 | DOPAMINE | EC50 | = | 209.0 | nM | 6.68 |