Assay Detail
Binding
CHEMBL971412
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Inhibition of human recombinant HDAC6
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Isoxazole moiety in the linker region of HDAC inhibitors adjacent to the Zn-chelating group: effects on HDAC biology and antiproliferative activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 6.93 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL511212 | — | — | 1 | 8.52 |
| CHEMBL468935 | — | — | 1 | 8.52 |
| CHEMBL512644 | — | — | 1 | 8.30 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 7.85 |
| CHEMBL511715 | — | — | 1 | 7.29 |
| CHEMBL469134 | — | — | 1 | 7.17 |
| CHEMBL511432 | — | — | 1 | 7.09 |
| CHEMBL468527 | — | — | 1 | 6.05 |
| CHEMBL466459 | — | — | 1 | 5.77 |
| CHEMBL466171 | — | — | 1 | 4.91 |
| CHEMBL507592 | — | — | 1 | 4.77 |
| CHEMBL466031 | — | — | 1 | - |
| CHEMBL466032 | — | — | 1 | - |
| CHEMBL466033 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL511212 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL468935 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL512644 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL511715 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL469134 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL511432 | — | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL468527 | — | IC50 | = | 885.0 | nM | 6.05 |
| CHEMBL466459 | — | IC50 | = | 1710.0 | nM | 5.77 |
| CHEMBL466171 | — | IC50 | = | 12300.0 | nM | 4.91 |
| CHEMBL507592 | — | IC50 | = | 17100.0 | nM | 4.77 |
| CHEMBL466031 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL466032 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL466033 | — | IC50 | > | 30000.0 | nM | - |