Assay Detail
Functional
CHEMBL971417
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Antiproliferative activity against human MIAPaCa2 cells by MTT assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MIA PaCa-2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Isoxazole moiety in the linker region of HDAC inhibitors adjacent to the Zn-chelating group: effects on HDAC biology and antiproliferative activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.04 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 6.00 |
| CHEMBL469134 | — | — | 1 | 5.40 |
| CHEMBL511432 | — | — | 1 | 5.05 |
| CHEMBL511715 | — | — | 1 | 4.62 |
| CHEMBL507592 | — | — | 1 | 4.62 |
| CHEMBL468527 | — | — | 1 | 4.52 |
| CHEMBL466031 | — | — | 1 | - |
| CHEMBL466032 | — | — | 1 | - |
| CHEMBL466033 | — | — | 1 | - |
| CHEMBL466171 | — | — | 1 | - |
| CHEMBL466459 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL98 | VORINOSTAT | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL469134 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL511432 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL511715 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL507592 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL468527 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL466031 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL466032 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL466033 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL466171 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL466459 | — | IC50 | > | 50000.0 | nM | - |