Assay Detail
Functional
CHEMBL971431
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human P2Y2 receptor expressed in human 1321N1 cells coexpressing phospholipase C-activating G protein assessed as inositol phosphate production by scintillation proximity assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | 1321-N1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and P2Y receptor activity of nucleoside 5'-phosphonate derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 5.88 | 7.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL14249 | ADENOSINE TRIPHOSPHATE | 2.0 | 1 | 7.07 |
| CHEMBL523850 | — | — | 1 | 6.00 |
| CHEMBL493370 | — | — | 1 | 5.85 |
| CHEMBL522015 | — | — | 1 | 5.80 |
| CHEMBL505857 | — | — | 1 | 5.47 |
| CHEMBL493371 | — | — | 1 | 5.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL14249 | ADENOSINE TRIPHOSPHATE | EC50 | = | 85.0 | nM | 7.07 |
| CHEMBL523850 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL493370 | — | EC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL522015 | — | EC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL505857 | — | EC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL493371 | — | EC50 | = | 8600.0 | nM | 5.07 |