Assay Detail
Binding
CHEMBL971468
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Displacement of radioligand from human recombinant DP1 receptor expressed in HEK293 cells by scintillation proximity assay
35
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of potent and selective DP1 receptor antagonists in the azaindole series.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 35 | 8.76 | 9.49 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL483991 | — | — | 1 | 9.49 |
| CHEMBL520007 | — | — | 1 | 9.41 |
| CHEMBL484779 | — | — | 1 | 9.41 |
| CHEMBL483159 | — | — | 1 | 9.28 |
| CHEMBL484778 | — | — | 1 | 9.19 |
| CHEMBL484777 | — | — | 1 | 9.17 |
| CHEMBL483346 | — | — | 1 | 9.15 |
| CHEMBL483154 | — | — | 1 | 9.13 |
| CHEMBL482744 | — | — | 1 | 9.10 |
| CHEMBL518988 | — | — | 1 | 9.06 |
| CHEMBL509685 | — | — | 1 | 9.06 |
| CHEMBL482550 | — | — | 1 | 9.04 |
| CHEMBL483152 | — | — | 1 | 9.00 |
| CHEMBL514964 | — | — | 1 | 9.00 |
| CHEMBL521122 | — | — | 1 | 9.00 |
| CHEMBL518987 | — | — | 1 | 8.94 |
| CHEMBL484404 | — | — | 1 | 8.92 |
| CHEMBL520480 | — | — | 1 | 8.89 |
| CHEMBL474502 | — | — | 1 | 8.89 |
| CHEMBL506909 | — | — | 1 | 8.85 |
| CHEMBL519862 | — | — | 1 | 8.80 |
| CHEMBL482547 | — | — | 1 | 8.74 |
| CHEMBL484327 | — | — | 1 | 8.72 |
| CHEMBL514802 | — | — | 1 | 8.68 |
| CHEMBL521290 | — | — | 1 | 8.64 |
| CHEMBL519803 | — | — | 1 | 8.60 |
| CHEMBL483939 | — | — | 1 | 8.48 |
| CHEMBL484130 | — | — | 1 | 8.43 |
| CHEMBL520481 | — | — | 1 | 8.43 |
| CHEMBL484525 | — | — | 1 | 8.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL483991 | — | Ki | = | 0.32 | nM | 9.49 |
| CHEMBL520007 | — | Ki | = | 0.39 | nM | 9.41 |
| CHEMBL484779 | — | Ki | = | 0.39 | nM | 9.41 |
| CHEMBL483159 | — | Ki | = | 0.53 | nM | 9.28 |
| CHEMBL484778 | — | Ki | = | 0.64 | nM | 9.19 |
| CHEMBL484777 | — | Ki | = | 0.67 | nM | 9.17 |
| CHEMBL483346 | — | Ki | = | 0.71 | nM | 9.15 |
| CHEMBL483154 | — | Ki | = | 0.74 | nM | 9.13 |
| CHEMBL482744 | — | Ki | = | 0.8 | nM | 9.10 |
| CHEMBL518988 | — | Ki | = | 0.88 | nM | 9.06 |
| CHEMBL509685 | — | Ki | = | 0.88 | nM | 9.06 |
| CHEMBL482550 | — | Ki | = | 0.91 | nM | 9.04 |
| CHEMBL483152 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL514964 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL521122 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL518987 | — | Ki | = | 1.14 | nM | 8.94 |
| CHEMBL484404 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL520480 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL474502 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL506909 | — | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL519862 | — | Ki | = | 1.6 | nM | 8.80 |
| CHEMBL482547 | — | Ki | = | 1.8 | nM | 8.74 |
| CHEMBL484327 | — | Ki | = | 1.9 | nM | 8.72 |
| CHEMBL514802 | — | Ki | = | 2.1 | nM | 8.68 |
| CHEMBL521290 | — | Ki | = | 2.3 | nM | 8.64 |
| CHEMBL519803 | — | Ki | = | 2.5 | nM | 8.60 |
| CHEMBL483939 | — | Ki | = | 3.3 | nM | 8.48 |
| CHEMBL484130 | — | Ki | = | 3.7 | nM | 8.43 |
| CHEMBL520481 | — | Ki | = | 3.7 | nM | 8.43 |
| CHEMBL484525 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL485535 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL482548 | — | Ki | = | 12.4 | nM | 7.91 |
| CHEMBL474702 | — | Ki | = | 13.6 | nM | 7.87 |
| CHEMBL482743 | — | Ki | = | 16.3 | nM | 7.79 |
| CHEMBL482953 | — | Ki | = | 107.4 | nM | 6.97 |