Assay Detail
Binding
CHEMBL971586
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Inhibition of human adrenal corticoid CYP11B2 expressed in chinese hamster V79 MZh cells
36
Total Activities
36
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | V79 MZh |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel aldosterone synthase inhibitors with extended carbocyclic skeleton by a combined ligand-based and structure-based drug design approach.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 36 | 7.73 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL9298 | FADROZOLE | 2.0 | 1 | 9.00 |
| CHEMBL524011 | — | — | 1 | 8.57 |
| CHEMBL522860 | — | — | 1 | 8.52 |
| CHEMBL494712 | — | — | 1 | 8.41 |
| CHEMBL494315 | — | — | 1 | 8.30 |
| CHEMBL362968 | — | — | 1 | 8.21 |
| CHEMBL493089 | — | — | 1 | 8.12 |
| CHEMBL446775 | — | — | 1 | 8.11 |
| CHEMBL493082 | — | — | 1 | 8.11 |
| CHEMBL494713 | — | — | 1 | 7.96 |
| CHEMBL212473 | — | — | 1 | 7.96 |
| CHEMBL495333 | — | — | 1 | 7.62 |
| CHEMBL377766 | — | — | 1 | 7.60 |
| CHEMBL213587 | — | — | 1 | 7.55 |
| CHEMBL365735 | — | — | 1 | 7.55 |
| CHEMBL492892 | — | — | 1 | 7.55 |
| CHEMBL492891 | — | — | 1 | 7.52 |
| CHEMBL523196 | — | — | 1 | 7.28 |
| CHEMBL501779 | — | — | 1 | 7.19 |
| CHEMBL213588 | — | — | 1 | 7.02 |
| CHEMBL494515 | — | — | 1 | 6.92 |
| CHEMBL158635 | — | — | 1 | 6.91 |
| CHEMBL493485 | — | — | 1 | 6.81 |
| CHEMBL516643 | — | — | 1 | 6.73 |
| CHEMBL209047 | — | — | 1 | - |
| CHEMBL450201 | — | — | 1 | - |
| CHEMBL460769 | — | — | 1 | - |
| CHEMBL516647 | — | — | 1 | - |
| CHEMBL461618 | — | — | 1 | - |
| CHEMBL495340 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL9298 | FADROZOLE | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL524011 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL522860 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL494712 | — | IC50 | = | 3.9 | nM | 8.41 |
| CHEMBL494315 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL362968 | — | IC50 | = | 6.2 | nM | 8.21 |
| CHEMBL493089 | — | IC50 | = | 7.6 | nM | 8.12 |
| CHEMBL446775 | — | IC50 | = | 7.7 | nM | 8.11 |
| CHEMBL493082 | — | IC50 | = | 7.8 | nM | 8.11 |
| CHEMBL212473 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL494713 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL495333 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL377766 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL492892 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL365735 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL213587 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL492891 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL523196 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL501779 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL213588 | — | IC50 | = | 95.0 | nM | 7.02 |
| CHEMBL494515 | — | IC50 | = | 119.0 | nM | 6.92 |
| CHEMBL158635 | — | IC50 | = | 124.0 | nM | 6.91 |
| CHEMBL493485 | — | IC50 | = | 154.0 | nM | 6.81 |
| CHEMBL516643 | — | IC50 | = | 187.0 | nM | 6.73 |
| CHEMBL212168 | — | IC50 | - | — | - | |
| CHEMBL492876 | — | IC50 | - | — | - | |
| CHEMBL493081 | — | IC50 | - | — | - | |
| CHEMBL494714 | — | IC50 | - | — | - | |
| CHEMBL495140 | — | IC50 | - | — | - | |
| CHEMBL523884 | — | IC50 | - | — | - | |
| CHEMBL495340 | — | IC50 | - | — | - | |
| CHEMBL461618 | — | IC50 | - | — | - | |
| CHEMBL516647 | — | IC50 | - | — | - | |
| CHEMBL460769 | — | IC50 | - | — | - | |
| CHEMBL450201 | — | IC50 | - | — | - | |
| CHEMBL209047 | — | IC50 | - | — | - |