Assay Detail
Binding
CHEMBL971698
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Inhibition of CDK2/Cyclin A by radiometric assay
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Identification of N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide (AT7519), a novel cyclin dependent kinase inhibitor using fragment-based X-ray crystallography and structure based drug design.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 29 | 6.25 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL518383 | — | — | 1 | 8.52 |
| CHEMBL456963 | — | — | 1 | 7.92 |
| CHEMBL457177 | — | — | 1 | 7.72 |
| CHEMBL510578 | — | — | 1 | 7.60 |
| CHEMBL509730 | — | — | 1 | 7.52 |
| CHEMBL507167 | — | — | 1 | 7.42 |
| CHEMBL498659 | — | — | 1 | 7.36 |
| CHEMBL445813 | AT-7519 | 2.0 | 1 | 7.33 |
| CHEMBL463579 | — | — | 1 | 7.05 |
| CHEMBL497477 | — | — | 1 | 6.96 |
| CHEMBL457388 | — | — | 1 | 6.85 |
| CHEMBL463580 | — | — | 1 | 6.85 |
| CHEMBL497306 | — | — | 1 | 6.46 |
| CHEMBL503917 | — | — | 1 | 6.43 |
| CHEMBL14762 | SELICICLIB | 2.0 | 1 | 6.43 |
| CHEMBL455946 | — | — | 1 | 6.18 |
| CHEMBL443198 | — | — | 1 | 6.14 |
| CHEMBL448316 | — | — | 1 | 6.12 |
| CHEMBL456163 | — | — | 1 | 6.07 |
| CHEMBL458926 | — | — | 1 | 5.82 |
| CHEMBL457208 | — | — | 1 | 5.80 |
| CHEMBL487738 | — | — | 1 | 5.72 |
| CHEMBL508964 | — | — | 1 | 5.52 |
| CHEMBL448853 | — | — | 1 | 5.16 |
| CHEMBL495758 | — | — | 1 | 4.60 |
| CHEMBL499521 | — | — | 1 | 4.07 |
| CHEMBL445420 | — | — | 1 | 4.01 |
| CHEMBL457047 | — | — | 1 | 3.92 |
| CHEMBL86795 | INDAZOLE | — | 1 | 3.73 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL518383 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL456963 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL457177 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL510578 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL509730 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL507167 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL498659 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL445813 | AT-7519 | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL463579 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL497477 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL457388 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL463580 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL497306 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL503917 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL14762 | SELICICLIB | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL455946 | — | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL443198 | — | IC50 | = | 730.0 | nM | 6.14 |
| CHEMBL448316 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL456163 | — | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL458926 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL457208 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL487738 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL508964 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL448853 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL495758 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL499521 | — | IC50 | = | 85000.0 | nM | 4.07 |
| CHEMBL445420 | — | IC50 | = | 97000.0 | nM | 4.01 |
| CHEMBL457047 | — | IC50 | = | 120000.0 | nM | 3.92 |
| CHEMBL86795 | INDAZOLE | IC50 | = | 185000.0 | nM | 3.73 |