Assay Detail
Binding
CHEMBL971700
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Inhibition of CDK1/Cyclin B by radiometric assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Cyclin-dependent kinase 1/cyclin B1 (CHEMBL1907602) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Identification of N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide (AT7519), a novel cyclin dependent kinase inhibitor using fragment-based X-ray crystallography and structure based drug design.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.02 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL518383 | — | — | 1 | 8.00 |
| CHEMBL498659 | — | — | 1 | 7.42 |
| CHEMBL457177 | — | — | 1 | 7.35 |
| CHEMBL456963 | — | — | 1 | 7.26 |
| CHEMBL445813 | AT-7519 | 2.0 | 1 | 6.72 |
| CHEMBL507167 | — | — | 1 | 6.36 |
| CHEMBL457388 | — | — | 1 | 6.01 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL518383 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL498659 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL457177 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL456963 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL445813 | AT-7519 | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL507167 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL457388 | — | IC50 | = | 980.0 | nM | 6.01 |