Assay Detail
Binding
CHEMBL971823
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Inhibition of human recombinant HGF-mediated cMet phosphorylation in human PC3 cells
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | PC-3 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis, and biological evaluation of potent c-Met inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.91 | 7.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL453737 | — | — | 1 | 7.19 |
| CHEMBL447602 | — | — | 1 | 7.16 |
| CHEMBL444560 | — | — | 1 | 6.79 |
| CHEMBL461648 | — | — | 1 | 6.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL453737 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL447602 | — | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL444560 | — | IC50 | = | 161.0 | nM | 6.79 |
| CHEMBL461648 | — | IC50 | = | 313.0 | nM | 6.50 |