Assay Detail

CHEMBL972058

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Functional

Inhibition of TPA-induced NF-kappaB activation in human HepG2 cells by luciferase assay

ChEMBL ↗

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Target

HepG2 (CHEMBL395) ↗

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Primary target HepG2

CHEMBL395

Anchored from Assay target.

Protein identity HepG2

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	HepG2
Confidence	1 — Organism
Curated By	Autocuration

Target

HepG2 (CHEMBL395) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

Bioactive dammarane triterpenes from the mangrove plant Bruguiera gymnorrhiza.

Homhual S, Bunyapraphatsara N, Kondratyuk T, Herunsalee A, Chaukul W, Pezzuto JM, Fong HH, Zhang HJ.
J Nat Prod (2006) 69 : 421 -424
PubMed 16562850 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	5.85	5.85

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL504631	BRUGUIERIN A	—	1	5.85

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL504631	BRUGUIERIN A	IC50	=	1400.0	nM	5.85