Assay Detail
Functional
CHEMBL972059
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Induction of ARE in human HepG2 cells by luciferase assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HepG2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Bioactive dammarane triterpenes from the mangrove plant Bruguiera gymnorrhiza.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 4.99 | 5.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL48802 | SULFORAPHANE | 3.0 | 1 | 5.40 |
| CHEMBL504631 | BRUGUIERIN A | — | 1 | 5.11 |
| CHEMBL26260 | BETA-NAPHTHOFLAVONE | — | 1 | 5.10 |
| CHEMBL447269 | BRUGUIERIN B | — | 1 | 5.03 |
| CHEMBL503931 | BRUGUIERIN C | — | 1 | 4.80 |
| CHEMBL294099 | — | — | 1 | 4.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL48802 | SULFORAPHANE | EC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL504631 | BRUGUIERIN A | EC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL26260 | BETA-NAPHTHOFLAVONE | EC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL447269 | BRUGUIERIN B | EC50 | = | 9400.0 | nM | 5.03 |
| CHEMBL503931 | BRUGUIERIN C | EC50 | = | 15700.0 | nM | 4.80 |
| CHEMBL294099 | — | EC50 | = | 30000.0 | nM | 4.52 |