Assay Detail
Binding
CHEMBL972265
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of bovine brain tubulin by microtubule depolymerization assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Antiglioma action of xanthones from Gentiana kochiana: Mechanistic and structure-activity requirements.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.19 | 5.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 5.62 |
| CHEMBL187044 | GENTIAKOCHIANIN | — | 1 | 4.75 |
| CHEMBL467590 | GETIACAULEIN | — | 1 | - |
| CHEMBL184574 | DEMETHYLBELLIDIFOLIN | — | 1 | - |
| CHEMBL185776 | BELLIDIFOLIN | — | 1 | - |
| CHEMBL26323 | DECUSSATIN | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL428647 | PACLITAXEL | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL187044 | GENTIAKOCHIANIN | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL467590 | GETIACAULEIN | IC50 | > | 50000.0 | nM | - |
| CHEMBL184574 | DEMETHYLBELLIDIFOLIN | IC50 | > | 50000.0 | nM | - |
| CHEMBL185776 | BELLIDIFOLIN | IC50 | > | 50000.0 | nM | - |
| CHEMBL26323 | DECUSSATIN | IC50 | - | — | - |