Assay Detail
Binding
CHEMBL972293
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Inhibition of hepatitis A virus 3C proteinase by microplate assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Hepatovirus A |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Heteroaromatic ester inhibitors of hepatitis A virus 3C proteinase: Evaluation of mode of action.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.58 | 7.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL222234 | — | — | 1 | 7.28 |
| CHEMBL448492 | — | — | 1 | 6.85 |
| CHEMBL521883 | — | — | 1 | 6.60 |
| CHEMBL222840 | — | — | 1 | 6.47 |
| CHEMBL468553 | — | — | 1 | 6.33 |
| CHEMBL500892 | — | — | 1 | 5.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL222234 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL448492 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL521883 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL222840 | — | IC50 | = | 338.0 | nM | 6.47 |
| CHEMBL468553 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL500892 | — | IC50 | = | 1200.0 | nM | 5.92 |