Assay Detail
Binding
CHEMBL972657
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Inhibition of HCV 1b isolate BK NS5B Cdelta21 polymerase
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Hepatitis C virus (isolate BK) |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of (R)-6-cyclopentyl-6-(2-(2,6-diethylpyridin-4-yl)ethyl)-3-((5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)methyl)-4-hydroxy-5,6-dihydropyran-2-one (PF-00868554) as a potent and orally available hepatitis C virus polymerase inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 7.95 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL230743 | — | — | 1 | 8.70 |
| CHEMBL230744 | — | — | 1 | 8.52 |
| CHEMBL514640 | — | — | 1 | 8.52 |
| CHEMBL509746 | — | — | 1 | 8.30 |
| CHEMBL522658 | — | — | 1 | 8.22 |
| CHEMBL524103 | — | — | 1 | 8.15 |
| CHEMBL490672 | FILIBUVIR | 3.0 | 1 | 8.15 |
| CHEMBL515872 | — | — | 1 | 8.10 |
| CHEMBL489476 | — | — | 1 | 8.10 |
| CHEMBL474322 | — | — | 1 | 8.00 |
| CHEMBL522458 | — | — | 1 | 8.00 |
| CHEMBL489295 | — | — | 1 | 7.92 |
| CHEMBL490671 | — | — | 1 | 7.80 |
| CHEMBL472914 | — | — | 1 | 7.06 |
| CHEMBL516051 | — | — | 1 | 6.85 |
| CHEMBL472913 | — | — | 1 | 6.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL230743 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL230744 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL514640 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL509746 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL522658 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL524103 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL490672 | FILIBUVIR | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL515872 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL489476 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL474322 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL522458 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL489295 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL490671 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL472914 | — | IC50 | = | 88.0 | nM | 7.06 |
| CHEMBL516051 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL472913 | — | IC50 | = | 180.0 | nM | 6.75 |