Assay Detail
Functional
CHEMBL972693
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at PPARdelta transfected in HEK293 cells by GAL4 transactivation assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | HEK293 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
Peroxisome proliferator-activated receptor delta (CHEMBL3979) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Improvement of the transactivation activity of phenylpropanoic acid-type peroxisome proliferator-activated receptor pan agonists: effect of introduction of fluorine at the linker part.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 15 | 6.95 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL462982 | — | — | 1 | 7.70 |
| CHEMBL514264 | — | — | 1 | 7.60 |
| CHEMBL457623 | — | — | 1 | 7.55 |
| CHEMBL387914 | — | — | 1 | 7.54 |
| CHEMBL457405 | — | — | 1 | 7.26 |
| CHEMBL455957 | — | — | 1 | 7.23 |
| CHEMBL514256 | — | — | 1 | 7.22 |
| CHEMBL456974 | — | — | 1 | 7.03 |
| CHEMBL402840 | — | — | 1 | 6.92 |
| CHEMBL118939 | — | — | 1 | 6.89 |
| CHEMBL456355 | — | — | 1 | 6.75 |
| CHEMBL456973 | — | — | 1 | 6.55 |
| CHEMBL456752 | — | — | 1 | 6.26 |
| CHEMBL402161 | — | — | 1 | 6.03 |
| CHEMBL456753 | — | — | 1 | 5.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL462982 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL514264 | — | EC50 | = | 25.0 | nM | 7.60 |
| CHEMBL457623 | — | EC50 | = | 28.0 | nM | 7.55 |
| CHEMBL387914 | — | EC50 | = | 29.0 | nM | 7.54 |
| CHEMBL457405 | — | EC50 | = | 55.0 | nM | 7.26 |
| CHEMBL455957 | — | EC50 | = | 59.0 | nM | 7.23 |
| CHEMBL514256 | — | EC50 | = | 60.0 | nM | 7.22 |
| CHEMBL456974 | — | EC50 | = | 94.0 | nM | 7.03 |
| CHEMBL402840 | — | EC50 | = | 120.0 | nM | 6.92 |
| CHEMBL118939 | — | EC50 | = | 130.0 | nM | 6.89 |
| CHEMBL456355 | — | EC50 | = | 180.0 | nM | 6.75 |
| CHEMBL456973 | — | EC50 | = | 280.0 | nM | 6.55 |
| CHEMBL456752 | — | EC50 | = | 550.0 | nM | 6.26 |
| CHEMBL402161 | — | EC50 | = | 940.0 | nM | 6.03 |
| CHEMBL456753 | — | EC50 | = | 2200.0 | nM | 5.66 |