Assay Detail
Binding
CHEMBL972700
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Inhibition of HCV 1b BK delta21 NS5B delta21 polymerase
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Hepatitis C virus subtype 1b |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
4-(1,1-Dioxo-1,4-dihydro-1lambda6-benzo[1,4]thiazin-3-yl)-5-hydroxy-2H-pyridazin-3-ones as potent inhibitors of HCV NS5B polymerase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 6.50 | 7.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL457611 | — | — | 1 | 7.82 |
| CHEMBL455908 | — | — | 1 | 7.75 |
| CHEMBL401595 | — | — | 1 | 7.64 |
| CHEMBL524461 | — | — | 1 | 7.57 |
| CHEMBL457176 | — | — | 1 | 7.41 |
| CHEMBL456132 | — | — | 1 | 6.60 |
| CHEMBL525739 | — | — | 1 | 6.36 |
| CHEMBL513932 | — | — | 1 | 5.80 |
| CHEMBL456343 | — | — | 1 | 5.80 |
| CHEMBL401931 | — | — | 1 | 5.31 |
| CHEMBL505717 | — | — | 1 | 5.05 |
| CHEMBL498308 | — | — | 1 | 4.92 |
| CHEMBL457175 | — | — | 1 | - |
| CHEMBL456104 | — | — | 1 | - |
| CHEMBL401974 | — | — | 1 | - |
| CHEMBL497491 | — | — | 1 | - |
| CHEMBL401825 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL457611 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL455908 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL401595 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL524461 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL457176 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL456132 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL525739 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL513932 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL456343 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL401931 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL505717 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL498308 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL457175 | — | IC50 | < | 10.0 | nM | - |
| CHEMBL456104 | — | IC50 | < | 10.0 | nM | - |
| CHEMBL401974 | — | IC50 | < | 10.0 | nM | - |
| CHEMBL497491 | — | IC50 | < | 10.0 | nM | - |
| CHEMBL401825 | — | IC50 | < | 10.0 | nM | - |