Assay Detail
Binding
CHEMBL972705
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]1,25-(OH)2D3 from bovine thymus vitamin D receptor
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
A new class of vitamin D analogues that induce structural rearrangement of the ligand-binding pocket of the receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 9 | 8.44 | 10.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL846 | CALCITRIOL | 4.0 | 1 | 10.30 |
| CHEMBL454123 | — | — | 1 | 8.92 |
| CHEMBL454124 | — | — | 1 | 8.70 |
| CHEMBL454141 | — | — | 1 | 8.47 |
| CHEMBL454947 | — | — | 1 | 8.42 |
| CHEMBL454122 | — | — | 1 | 7.96 |
| CHEMBL507787 | — | — | 1 | 7.80 |
| CHEMBL454925 | — | — | 1 | 7.70 |
| CHEMBL454142 | — | — | 1 | 7.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL846 | CALCITRIOL | EC50 | = | 0.05 | nM | 10.30 |
| CHEMBL454123 | — | EC50 | = | 1.2 | nM | 8.92 |
| CHEMBL454124 | — | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL454141 | — | EC50 | = | 3.4 | nM | 8.47 |
| CHEMBL454947 | — | EC50 | = | 3.8 | nM | 8.42 |
| CHEMBL454122 | — | EC50 | = | 11.0 | nM | 7.96 |
| CHEMBL507787 | — | EC50 | = | 16.0 | nM | 7.80 |
| CHEMBL454925 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL454142 | — | EC50 | = | 20.0 | nM | 7.70 |