Assay Detail

CHEMBL972824

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Functional

Cytotoxicity against human K-562 cells after 48 hrs by SRB assay

ChEMBL ↗

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Target

K562 (CHEMBL385) ↗

Open DB target context

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Primary target K562

CHEMBL385

Anchored from Assay target.

Protein identity K562

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	K562
Confidence	1 — Organism
Curated By	Autocuration

Target

K562 (CHEMBL385) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

Cytotoxic cis-fused bicyclic sesquiterpenoids from Jatropha neopauciflora.

García A, Delgado G.
J Nat Prod (2006) 69 : 1618 -1621
PubMed 17125233 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	2	5.53	6.55

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL53463	DOXORUBICIN	4.0	1	6.55
CHEMBL462795	CALENDULADIOL	—	1	4.50

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL53463	DOXORUBICIN	IC50	=	280.0	nM	6.55
CHEMBL462795	CALENDULADIOL	IC50	=	31440.0	nM	4.50