Assay Detail
ADMET
CHEMBL972845
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Antiproliferative activity against mouse J774 cells assessed as reduction of cell growth after 72 hrs by MTT method
15
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Mus musculus |
| Cell Type | J774 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Antiproliferative triterpene saponins from Trevesia palmata.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 7.07 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1425 | MERCAPTOPURINE ANHYDROUS | 4.0 | 1 | 8.52 |
| CHEMBL506880 | HEDERASAPONIN B | — | 1 | 7.22 |
| CHEMBL501682 | — | — | 2 | 7.16 |
| CHEMBL508736 | — | — | 1 | 7.00 |
| CHEMBL506829 | — | — | 1 | 7.00 |
| CHEMBL505847 | — | — | 1 | 6.96 |
| CHEMBL508634 | — | — | 1 | 6.75 |
| CHEMBL506550 | — | — | 1 | 6.72 |
| CHEMBL451591 | — | — | 1 | 6.34 |
| CHEMBL501032 | — | — | 1 | - |
| CHEMBL506816 | — | — | 1 | - |
| CHEMBL475806 | — | — | 1 | - |
| CHEMBL503131 | — | — | 1 | - |
| CHEMBL502407 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1425 | MERCAPTOPURINE ANHYDROUS | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL506880 | HEDERASAPONIN B | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL501682 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL508736 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL506829 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL505847 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL508634 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL506550 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL451591 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL501032 | — | IC50 | - | — | - | |
| CHEMBL506816 | — | IC50 | - | — | - | |
| CHEMBL501682 | — | IC50 | - | — | - | |
| CHEMBL475806 | — | IC50 | - | — | - | |
| CHEMBL503131 | — | IC50 | - | — | - | |
| CHEMBL502407 | — | IC50 | - | — | - |