Assay Detail

CHEMBL972855

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding

Inhibition of human synovial sPLA2

ChEMBL ↗

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Target

Unchecked (CHEMBL612545) ↗

Open DB target context

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Primary target Unchecked

CHEMBL612545

Anchored from Assay target.

Protein identity Unchecked

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Homo sapiens
Confidence	0 — Uncurated / Unknown
Curated By	Autocuration

Target

Unchecked (CHEMBL612545) ↗

Type

UNCHECKED

Publication

New pyridinium alkaloids from a marine sponge of the genus Spongia with a human phospholipase A(2) inhibitor profile.

De Marino S, Iorizzi M, Zollo F, Debitus C, Menou JL, Ospina LF, Alcaraz MJ, Payá M.
J Nat Prod (2000) 63 : 322 -326
PubMed 10757711 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	2	5.33	5.41

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL497528	MANOLIDE	—	1	5.41
CHEMBL496249	PETROSASPONGIOLIDE P	—	1	5.24

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL497528	MANOLIDE	IC50	=	3900.0	nM	5.41
CHEMBL496249	PETROSASPONGIOLIDE P	IC50	=	5800.0	nM	5.24