Assay Detail
Functional
CHEMBL973186
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Antileishmanial activity against Leishmania braziliensis MHOM/BR/95/IOCL-2033 promastigotes after 24 hrs
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Leishmania braziliensis |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
A pyrimidine-beta-carboline and other alkaloids from Annona foetida with antileishmanial activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.74 | 5.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL55 | PENTAMIDINE | 4.0 | 1 | 5.54 |
| CHEMBL501413 | ANNOMONTINE | — | 1 | 4.46 |
| CHEMBL37736 | LIRIODENINE | — | 1 | 4.23 |
| CHEMBL481059 | — | — | 1 | - |
| CHEMBL227533 | HOMOMOSCHATOLINE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL55 | PENTAMIDINE | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL501413 | ANNOMONTINE | IC50 | = | 34800.0 | nM | 4.46 |
| CHEMBL37736 | LIRIODENINE | IC50 | = | 58500.0 | nM | 4.23 |
| CHEMBL481059 | — | IC50 | = | 252700.0 | nM | - |
| CHEMBL227533 | HOMOMOSCHATOLINE | IC50 | = | 320800.0 | nM | - |