Assay Detail
Binding
CHEMBL973235
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of HIV1 reverse transcriptase in human LAI cells
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | LAI |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 reverse transcriptase (CHEMBL247) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Predicting binding modes from free energy calculations.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 34 | 7.25 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL177666 | — | — | 1 | 9.00 |
| CHEMBL177275 | — | — | 1 | 9.00 |
| CHEMBL426046 | — | — | 1 | 9.00 |
| CHEMBL368039 | — | — | 1 | 8.70 |
| CHEMBL175692 | — | — | 1 | 8.52 |
| CHEMBL176107 | — | — | 1 | 8.40 |
| CHEMBL180008 | — | — | 1 | 8.40 |
| CHEMBL175873 | — | — | 1 | 8.30 |
| CHEMBL177744 | — | — | 1 | 8.30 |
| CHEMBL177709 | — | — | 1 | 8.22 |
| CHEMBL177563 | — | — | 1 | 8.10 |
| CHEMBL339511 | — | — | 1 | 8.00 |
| CHEMBL367745 | — | — | 1 | 8.00 |
| CHEMBL360957 | — | — | 1 | 7.90 |
| CHEMBL174536 | — | — | 1 | 7.89 |
| CHEMBL174339 | — | — | 1 | 7.80 |
| CHEMBL175534 | — | — | 1 | 7.80 |
| CHEMBL369599 | — | — | 1 | 7.80 |
| CHEMBL174340 | — | — | 1 | 7.80 |
| CHEMBL424972 | — | — | 1 | 7.70 |
| CHEMBL178936 | — | — | 1 | 7.60 |
| CHEMBL338936 | — | — | 1 | 7.10 |
| CHEMBL175925 | — | — | 1 | 6.90 |
| CHEMBL178061 | — | — | 1 | 6.80 |
| CHEMBL177491 | — | — | 1 | 6.60 |
| CHEMBL369148 | — | — | 1 | 6.50 |
| CHEMBL129144 | — | — | 1 | 6.40 |
| CHEMBL175655 | — | — | 1 | 6.20 |
| CHEMBL177253 | — | — | 1 | 5.50 |
| CHEMBL128569 | — | — | 1 | 5.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL177666 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL426046 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL177275 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL368039 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL175692 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL176107 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL180008 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL177744 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL175873 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL177709 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL177563 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL339511 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL367745 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL360957 | — | IC50 | = | 12.6 | nM | 7.90 |
| CHEMBL174536 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL175534 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL369599 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL174339 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL174340 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL424972 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL178936 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL338936 | — | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL175925 | — | IC50 | = | 126.0 | nM | 6.90 |
| CHEMBL178061 | — | IC50 | = | 158.0 | nM | 6.80 |
| CHEMBL177491 | — | IC50 | = | 251.0 | nM | 6.60 |
| CHEMBL369148 | — | IC50 | = | 316.0 | nM | 6.50 |
| CHEMBL129144 | — | IC50 | = | 398.0 | nM | 6.40 |
| CHEMBL175655 | — | IC50 | = | 631.0 | nM | 6.20 |
| CHEMBL177253 | — | IC50 | = | 3162.0 | nM | 5.50 |
| CHEMBL128569 | — | IC50 | = | 3981.0 | nM | 5.40 |
| CHEMBL178043 | — | IC50 | = | 25119.0 | nM | 4.60 |
| CHEMBL179736 | — | IC50 | = | 50119.0 | nM | 4.30 |
| CHEMBL366811 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL435522 | — | IC50 | = | 100000.0 | nM | 4.00 |