Assay Detail
Functional
CHEMBL973255
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Cytotoxicity against mouse L1210 cells after 48 hrs
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | L1210 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and antiproliferative activity of some 3-benzylidene-2,3-dihydro-1-benzopyran-4-ones which display selective toxicity for malignant cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 4.45 | 5.67 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL852 | MELPHALAN | 4.0 | 1 | 5.67 |
| CHEMBL451747 | — | — | 1 | 4.74 |
| CHEMBL455122 | — | — | 1 | 4.44 |
| CHEMBL510057 | — | — | 1 | 4.41 |
| CHEMBL508286 | — | — | 1 | 4.33 |
| CHEMBL511011 | — | — | 1 | 4.17 |
| CHEMBL509587 | — | — | 1 | 4.15 |
| CHEMBL452006 | — | — | 1 | 4.09 |
| CHEMBL452001 | — | — | 1 | 4.04 |
| CHEMBL443096 | — | — | 1 | - |
| CHEMBL451746 | — | — | 1 | - |
| CHEMBL451745 | — | — | 1 | - |
| CHEMBL452004 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL852 | MELPHALAN | IC50 | = | 2130.0 | nM | 5.67 |
| CHEMBL451747 | — | IC50 | = | 18100.0 | nM | 4.74 |
| CHEMBL455122 | — | IC50 | = | 36300.0 | nM | 4.44 |
| CHEMBL510057 | — | IC50 | = | 38800.0 | nM | 4.41 |
| CHEMBL508286 | — | IC50 | = | 46900.0 | nM | 4.33 |
| CHEMBL511011 | — | IC50 | = | 67300.0 | nM | 4.17 |
| CHEMBL509587 | — | IC50 | = | 71400.0 | nM | 4.15 |
| CHEMBL452006 | — | IC50 | = | 80300.0 | nM | 4.09 |
| CHEMBL452001 | — | IC50 | = | 91000.0 | nM | 4.04 |
| CHEMBL443096 | — | IC50 | = | 124000.0 | nM | - |
| CHEMBL451746 | — | IC50 | = | 148000.0 | nM | - |
| CHEMBL451745 | — | IC50 | = | 254000.0 | nM | - |
| CHEMBL452004 | — | IC50 | = | 242000.0 | nM | - |